Studies on Digitalis Glycosides. XVII. Transformation of Cardenolides by Microorganisms. (3). 1β, 7β-Dihydroxy-digitoxigenin and 5β, 7β-Dihydroxydigitoxigenin.

Abstract

The structure and configuration of two kinds of dihydroxyl derivatives obtained by microbiological transformation of digitoxigenin with Absidia orchidis were discussed. One of them was shown to be 1β, 7β-dihydroxydigitoxigenin and the other 5β, 7β-dihydroxydigitoxigenin. This represents the first instance of the introduction of two hydroxyl groups into a cardiac aglycone by microbial oxidation.