Syntheses of Morphine-like Structures. I. 9-Hydroxymethyl-2, 5-dimethyl-6, 7-benzomorphan.

Abstract

9-Hydroxymethyl-2, 5-dimethyl-6, 7-benzomorphan has been synthesized by hydroboration reaction of 9-methylene-2, 5-dimethyl-6, 7-benzomorphan. Configuration of the newly introduced 9-hydroxymethyl group was confirmed as trans with 5-methyl group for the hydroaromatic ring.