Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Studies on Acetylenic Compounds. XXXIX. The Addition Reaction of Cyanogen Bromide to Acetylenic Compounds
Issei IwaiTadahiro IwashigeYasuo YuraNorio NakamuraKiyoshi Shinozaki
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1964 Volume 12 Issue 12 Pages 1446-1451

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Abstract

The addition of cyanogen bromide to an acetylenic bond was studied. Phenylacetylene reacted with cyanogen bromide in the presence of aluminum bromide to afford trans-β-bromocinnamonitrile. Similarly, p-bromo-and p-methoxyphenylacetylene, tolane and methylphenylacetylene yielded corresponding β-bromocinnamonitriles. Nevertheless, p-nitrophenylacetylene did not react with cyanogen bromide under the same conditions.

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© The Pharmaceutical Society of Japan
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