Reaction of Amide Homologs. XII. Reaction of N-Arylmethylene-1-acylamino-1-arylmethylamine with Active Methylene Compound.

Abstract

1-Acylaminoarylmethylation of ethyl malonate was effected in several cases by interaction of N-arylmethylene-1-acylamino-1-arylmethylamine in refluxing toluene solution with suspended sodium hydroxide powder. Ethyl cyanoacetate, phenylacetonitrile and malononitrile formed arylmethylene derivatives under the same condition as with ethyl malonate.