Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Metabolism of Drugs. XLVII. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (4)
Hisao TsukamotoSeisuke Terada
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1964 Volume 12 Issue 7 Pages 765-769


Metabolism of various alkyl p-hydroxybenzoates was investigated in rabbits using oral dose levels of 0.4 and 0.8 g./kg., and compared with than of p-hydroxybenzoic acid, which is a major metabolite of their esters. Metabolism of the esters was very rapid and excretion of the free p-hydroxybenzoic acid in the urine after administration was much less than that of p-hydroxybenzoic acid but output of the acid conjugated with glycine and glucuronic acid was much larger. When various alkyl esters were administered, those were converted into the free acid (25∼39%), glycine conjugate (15∼29%), ester-type glucuronide (5∼8%), ether-type glucuronide (10∼18%), and the sulfate (7∼12%) during 24 hours.

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