Absorption and Excretion of Drugs. XXVII. Effect of Nonionic Surface-Active Agents on Rectal Absorption of Sulfonamides

Abstract

The rectal absorption of sulfonamides were reduced by the addition of various nonionic surface-active agents. This reduction depends upon the entrapment of drug in micelles. The drug in micelles was also absorbed a little, and therefore the enhancement of drug absorption were obtained by solubilization of the drug remained as a solid in solution. The mechanism of drug absorption in the presence of nonionic surface-active agent can be explained by the concept that there are two ways of the passage of the free drug and of the drug in micelles.