Studies on Food Additives. XI. N-Glucosiduronate Formation of Arylurea in vivo and in vitro

Abstract

N-Glucosiduronates of arylureas excreted in the rabbit urine dosed with arylureas were isolated and confirmed to be identical with ammonium 1-[3-(aryl) ureido]-1-deoxy-D-glucopyranosiduronates which were synthesized from glucuronic acid and arylureas in pyridine. It is suggested that N-glucosiduronate conjugation is a general pathway of arylurea metabolism in the rabbit.