抄録
Dihydroxythymoquinone (DTQ) showed a marked inhibitory action on State-3 respiration of rat liver mitochondria with succinate, whereas, State-4 respiration was not inhibited. This inhibition was neither released by 2, 4-dinitrophenol nor other uncoupling agents. Completely DTQ inhibited oxidation of succinate by electron transport particles but the rate of inhibition was less than that of State-3 respiration by intact mitochondria. Reduction of cytochrome c by mitochondria with succinate was also inhibited. Succinate dehydrogenase was stimulated by DTQ.
