Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Syntheses of 3-Aminopropylguanidine Derivatives
Takeo UedaKumi Ishizaki
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1967 Volume 15 Issue 2 Pages 228-232

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Abstract
The fourteen compounds of 3-(substituted amino)propylguanidine were synthesized by reacting S-methylisothiourea sulfate with 3-(substituted amino)propylamine : 3-(substituted amino) propylamine having an aliphatic substituent group at 3-position were synthesized by reacting the aliphatic amine with acrylonitrile and by reducting with lithium aluminum hydride, while 3-(substituted amino)propylamine having an aromatic substituent group at 3-position, synthesized by the Ing-Manske modification of the Gabriel synthesis of primary amines.
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© The Pharmaceutical Society of Japan
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