Syntheses of 1-Dimethoxy-phenyl-3-alkylaminobutanols.I.

Abstract

The 1-derivatives of 1-(2, 5-dimethoxyphenyl)-3-alkylaminobutanols (III) were synthesized in order to investigate their pharmacological action. 2', 5'-Dimethoxycrotonophenone (I) which was prepared from hydroquinone dimethylether and crotonyl chloride by the Friedel-Crafts reaction, was reacted with various aliphatic amines to form 2-alkylamino-2', 5'-dimethoxy-propiophenone (II). Compounds (III) were obtained by the reaction of II with various Grignard's reagents.