Medicinal Chemical Studies on Antiplasmin Drugs. II. Separation of Stereoisomers of 4-Aminomethylcyclohexanecarboxylic Acid and Assignment of Their Configuration

Abstract

The stereoisomers of 4-aminomethylcyclohexanecarboxylic acid (I) and (II) were completely separated from their mixture, respectively, and it is proved that lowermelting isomer has the cis-configuration and higher-melting isomer whose antiplasmin activity is much potent has the trans-configuration.