Investigations on Pantothenic Acid and Its Related Compounds. XIV. Biochemical Studies. (8). Effect of Pantethine Analogs on Lactobacillus bulgaricus B1

Abstract

α-Methylpantethine, β-methylpantethine, homopantethine and oxypantetheine did not support the growth of L. bulgaricus B1 which required pantethine for its growth. These pantethine analogs were competitive inhibitors of pantethine in this microorganism, but they stimulated the bacterial growth at their subinhibitory concentrations in the presence of a small amount of pantethine. Magnitudes of their inhibitory effects were in the order of oxypantetheine≥homopantethine>β-methylpantethine>α-methylpantethine on the molar basis of the reduced form.