The Chemistry of Leucomycins. II. Glycosidic Linkages of Mycaminose and Mycarose on Leucomycin A₃

Abstract

It was previously reported that leucomycin A₃ is a macrolide antibiotic and composed of a lactone containing an aldehyde, O-acetyl, and O-methyl groups, mycaminose, and 4-O-isovaleryl mycarose. The present paper is concerned with the position of the aldehyde group and linkage of the two sugars, and it was found that mycaminose is linked with the aldehyde group at the γ-position through a β-glycosidic linkage, and isovalerylmycarose is linked with mycaminose at the 4-position through an α-glycosidic linkage.