Abstract
The disappearance of ethoxybenzamide from a rabbit plasma after an intravenous injection was studied. 1. The distribute phase after the injection could not be neglected, and the two compartmental model was applied to analize the time course of plasma concentration. 2. The iterative least square method with a digital computer was proposed to obtain pharmacokinetic constants and their statistical values. 3. The present method gave the unique parameters independent of personal error for drawing straight lines in the semilogarithmic plots of plasma concentration vs. time, and it could test the adoptability of data for the model.
