Inhibition of Tryptophan Pyrrolase of Rats by Phenols, Tryptophan Analogs and Hydrazine Derivatives

Abstract

Studies on the inhibition of tryptophan pyrrolase by eleven phenols, six tryptophan analogs and seven hydrazine derivatives were carried out. Serotonin, 5-hydroxytryptophan, epinephrine, norepinephrine and dopamine were found to inhibit the enzyme significantly. On the other hand, phenylhydrazine was the most potent inhibitor among the compounds tested. However, hydrazine hydrochloride, the parent compound of phenylhydrazine, was not inhibitory.