抄録
In order to examine the behaviors toward bromination 3β-acetoxy-5α, 13α-androstan-15-one (X) was prepared from the 17-keto steroid (I) according to the method worked out by Djerassi, et al. with the C/D-trans steroid (see Chart 1). On treatment with bromine in acetic acid in the presence of hydrogen bromide, bromination occurred exclusively at C-16 yielding a mixture of 16β-bromo and 16, 16-dibromo derivatives (XI and XII), which could be separated readily by preparative thin-layer chromatography.
