The Structure of Viscosin, A Peptide Antibiotic. II. Syntheses of D-and L-3-Hydroxyacylhexapeptides including the Proposed Structure of Viscosin and Its Optical Isomers

Abstract

Homologs of D- and L-3-hydroxyacylhexapeptide including compound (I-1c) and its optical isomers (I-1'c, I-2c, I-2'c) were synthesized by condensing the tripeptide subunit with the dipeptide subunit followed by azide coupling of the resulting pentapeptide with D-or L-3-hydroxyacylleucine, and their antibacterial properties were examined. None of the synthetic acylhexapeptides was identical with viscosin in both physical and chemical properties and antituberculous activity.