Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
3, 5-Propanopiperidine Derivatives as Potential Analgesics
EIJI OHKISADAO OIDAYOSHIHIKO OHASHIAKIRA YOSHIDAKATSUO KAMOSHITAHIROMU TAKAGI
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1974 Volume 22 Issue 5 Pages 1014-1021

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Abstract

4β-Methoxy-4α-phenyl-3α, 5α-propanopiperidine derivatives were prepared and tested biologically. Introduction of a m-hydroxy substituent into the phenyl group of these derivatives results in radical potentiation of analgesic and antitussive activities. Also, some N-carbamates of these derivatives exhibit appreciable anti-inflammatory effects with analgesic activity.

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© The Pharmaceutical Society of Japan
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