Studies on Peptides. XLI. Synthesis of the Protected Hexadecapeptide Corresponding to Positions 13 to 28 of the Basic Trypsin Inhibitor from Bovine Pancreas (Kunitz and Northrop)

Abstract

The protected hexadecapeptide, Z (OMe)-Pro-Cys (Bzl)-Lys (Z)-Ala-Arg (Tos)-Ile-Ile-Arg (Tos)-Tyr-Phe-Tyr-Asn-Ala-Lys (Z)-Ala-Gly-OH, corresponding to positions 13 through 28 of the basic trypsin inhibitor (Kunitz and Northrop) was synthesized by the successive azide coupling of four peptide subunits, H-Asn-Ala-Lys (Z)-Ala-Gly-OH, Z (OMe)-Tyr-Phe-Tyr-NHNH₂, Z (OMe)-Ala-Arg (Tos)-Ile-Ile-Arg (Tos)-NHNH₂ and Z (OMe)-Pro-Cys (Bzl)-Lys (Z)-NHNH₂.