Studies of Phosphorylation. III. Effect of Metallic Compound on the Phosphorylation of Alcohols, Phosphates, and Nucleosides by 8-Quinolyl Phosphates

Abstract

Influence of metallic compounds in phosphorylation of alcohols, phosphates, and nucleosides by means of 8-quinolyl phosphates was investigated. The mixed diesters of phosphoric acid (III) and pyrophosphates (V) were obtained in good yields when alcohols or phosphates were allowed to react with phenyl 8-quinolyl hydrogen phosphate (I) in the presence of a metallic compound. The effect of various metal components was examined and the copper [II] ion gave the best result. The reaction of tris (8-quinolyl) phosphate (VI) with nucleosides in the copper acetylacetonate resulted in the formation of corresponding nucleotides (VIII) in a high yield.