The Partition Coefficient of Aminouracil Derivatives

Abstract

The 1-octanol-water partition coefficient, P, of a number of substituted aminouracil derivatives was determined. The log P values were found to be composed additively from π values, (the increments in log P), attributable to each substituent at various positions. The π values of substituents are position specific and are governed by their hydrophobicity as well as by their electronic effect on the ring system.