Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
A New Method for the Preparation of 2-Hydroxymethyl-3-quinolinecarboxylic Acid Lactone Derivatives
栗原 拓史道田 隆平野 弘
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ジャーナル フリー

1975 年 23 巻 10 号 p. 2451-2453

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抄録
The reaction of 2-acetoxymethyl-3-acetylquinolines (V, VI) with sodium hydride gave 2-hydroxymethyl-3-quinolinecarboxylic acid lactones (IX, X), presumably formed with the migration of acetyl group. On the other hand, the fact that the reaction of 3-acetyl-2-benzoyloxymethylquinoline (VIII) with sodium hydride gave a lactone (IX) and acetophenone would strongly support for the mechanism of the lactone formation with the acyl migration.
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© The Pharmaceutical Society of Japan
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