Abstract
A study was made on the effect of dimensions on the disintegration time of tablet. The ln-ln plot of the disintegration time against the tablet thickness gave a straight line. The relation may be expressed simply by the equation, tD=KTn where tD is the disintegration time of the tablet which is compressed at a fixed pressure and has a constant diameter and thickness T, and K and n are constants. The relation expressed by this equation held good not only for directly compressed tablets but also for tablets made from granules. A tablet disintegration mechanism can be assumed by this equation. The rate of deaggregation of particles from the surface of the tablet changes with time depending upon the degree of the acceleration of deaggregation through the swelling of the disintegrant.
