Suppressive Effect of Cycloheximide-p-chlorocinnamate on Immune Responses in Mice

Abstract

Effects of cycloheximide-p-chlorocinnamate on humoral and cellular immune response in mice were investigated. The compound i) suppressed primary and secondary hemagglutinin response, ii) inhibited preferentially the production of IgG type antibodies, iii) reduced the number of hemolytic plaque forming cells in the spleen to nearly zero, and iv) suppressed the induction of delayed-type skin hypersensitivity and foot pad reaction.