Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Studies on Ergothioneine. V. Determination by High Performance Liquid Chromatography and Application to Metabolic Research
TADANORI MAYUMIHIROKO KAWANOYOSHIKO SAKAMOTOETSUJI SUEHISAYUICHI KAWAITAKAO HAMA
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1978 Volume 26 Issue 12 Pages 3772-3778

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Abstract

The high performance liquid chromatographic procedure was established for the determination of ergothioneine in biological materials. The procedure is also applicable to the purification of 3H-ergothioneine. The metabolism of ergothioneine given to rats was very slow ; the ergothioneine was not disappear even after 1 week fasting. The ergothioneine administrated was mostly concentrated in the liver and the level was 10 times as high as that in blood. All ergothioneine in the blood was found in blood corpuscles 24 hr after the administration.

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© The Pharmaceutical Society of Japan
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