Analysis of Permeation Profiles of Drugs from Systems containing Micelles

Abstract

A theoretical model is introduced to describe the permeation of drug through membranes from systems containing micelles. Taking distribution of drug between aqueous and micellar phases into account, an equation is derived which describes the permeation profile of drug from the system. Applicability of the model was experimentally tested employing local anesthetics, one of five surfactants, and silicone or ethylene-vinyl acetate copolymer membrane.