X-Ray Analysis of an Aminoglycoside Antibiotic P-2563 (P) Monohydrobromide

Abstract

The structure of an aminoglycoside antibiotic P-2563 (P) has been confirmed to be 3-O-(4-deoxyl-4-propionamido-α-D-glucopyranosyl)-1, 4-diamino-1, 4-dideoxyhexytol by the X-ray analysis of its monohydrobromide dihydrate crystals. The pyranose ring is expectedly in a chair form and its substituents are equatorial except that at C (1') which is axial. In the aminopolyol moiety, the arrangements around all of the C-C bonds are in staggered form. The carbon-carbon linkages from C (2) to C (6) are in s-trans zig-zag chain, and the five carbon atoms are almost coplanar. While the C (1) carbon atom is displaced from the plane resulting in the formation of an intramolecular hydrogen bond between the amino groups attached to C (1) and C (4).