Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Drug Nonequivalence. VI. Physico-chemical Studies on Polymorphism of Acetohexamide
黒田 耕司横山 照由梅田 常雄高岸 靖
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キーワード: DSC-TG curves
ジャーナル フリー

1978 年 26 巻 8 号 p. 2565-2568

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抄録
Form I, form II, and CHCl3-II type of acetohexamide are obtained by recrystallization from different solvents. X-ray diffraction patterns, infrared spectra, and differential scanning calorimeter curves of the CHCl3-II type are identical with those of form II, but CHCl3-II type contains a chloroform molecule, which cannot be removed by normal drying condition, and CHCl3-II type seems unsuitable for medical use. The solubility of form II is 1.2 times that of form I.
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© The Pharmaceutical Society of Japan
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