Reaction of 6-Substituted 1, 3-Dimethyluracils with Benzoyl Peroxide

Abstract

The reaction of 6-hydrazino-1, 3-dimethyluracil (II) with the benzoyloxy radical gave a tricyclic pyridazine derivative, 1, 3, 6, 8-tetramethyl-2, 4, 5, 7-tetraoxo-1, 2, 3, 4, 5, 6, 7, 8-octahydropyridazino [3, 4-d : 6, 5-d'] dipyrimidine (VII), while the reaction of 6-amino-1, 3-dimethyluracil (I) with the benzoyloxy radical afforded 6-amino-5-benzoyloxy-1, 3-dimethyluracil (VI). Treatment of VII with ammonia gave another tricyclic pyridazine derivative, 2, 4, 7, 9-tetramethyl-1, 3, 8-trioxo-1, 2, 3, 4, 7, 8, 9-heptahydropyrimido [4, 5-c] imidazo [4, 5-e] pyridazine (VIII).