Biochemically Active Substances from Microorganisms. V. Pyrrothines, Potent Platelet Aggregation Inhibitors of Microbial Origin

Abstract

Pyrrothines, known as broad-spectrum antibiotics, showed potent membrane stabilization and platelet anti-aggregant activities. Thiolutin, the most potent among them, is three times as active as indomethacin in HH, APA and CPA, but has no activity in the PD system. Pyrrothines exhibited strong inhibitory activity on 5-HT release from bovine platelets, which may be responsible in part for their platelet anti-aggregant activity.