Synthetic Approach directed at 1-Carbapenems and 1-Carbapenams

Abstract

Displacement reactions of the acetoxy group in 4-acetoxy-2-azetidinone (2) with aluminum enolates afforded 4-alkylazetidinones 4a, 5a, 10 and 11. The conversion of these azetidinones into 1-carba-penem or -penam compounds was studied.