著者所属：Department of Synthetic Chemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd. Department of Synthetic Chemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd. Department of Synthetic Chemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd. Department of Synthetic Chemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd. Department of Synthetic Chemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.
3-Acylamino-3-(5-fluorouracil-1-yl) propionates (3a, b) and 4-acylamino-4-(5-fluoro-uracil-1-yl) butyrates (3c-e) were synthesized from 3-acylamino-3-carboxypropionates (1a, b) and 4-acylamino-4-carboxybutyrates (1c-e), respectively, via electrochemical oxidation. Catalytic hydrogenolysis of the benzyl esters (3a, c, d) gave the corresponding carboxylic acids (4a', c', d') without cleavage of the geminal diamine moieties.
