Common Ion Effect of Chloride on the Dissolution Properties of Papaverine Hydrochloride

Abstract

The effect of chloride ion on the dissolution properties of papaverine-HCl was studied. The solubility and dissolution rate of papaverine-HCl were decreased by the common ion effect in a medium rich in chloride ion. The effect of chloride ion on the plasma levels of papaverine-HCl was also tested in rats, and lower plasma levels were observed when the drug was administered with 0.9% NaCl than in its absence. The results suggest that it may be possible to formulate sustained release preparations of papaverine-HCl by combination with NaCl.