Determination of Sulthiame in Plasma by High-Performance Liquid Chromatography

TSUNEO SADANAGA; KOZO HIKIDA; KATSUNOBU TAMETO; MICHIO NAKANISHI; YOSHIKAZU MATSUSHIMA; YOSUKE OHKURA

doi:10.1248/cpb.29.872

Chemical and Pharmaceutical Bulletin

Online ISSN : 1347-5223
Print ISSN : 0009-2363

Determination of Sulthiame in Plasma by High-Performance Liquid Chromatography

TSUNEO SADANAGA, KOZO HIKIDA, KATSUNOBU TAMETO, MICHIO NAKANISHI, YOSHIKAZU MATSUSHIMA, YOSUKE OHKURA

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Keywords: precise assay

JOURNALS FREE ACCESS

Volume 29 (1981) Issue 3 Pages 872-874

DOI https://doi.org/10.1248/cpb.29.872

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Abstract

A simple high-performance liquid chromatographic method for the determination of sulthiame, N-(4'-sulfamoylphenyl)-1, 4-butanesultam, in plasma is described. The method permits the accurate determination of the drug in plasma at concentrations as low as 150 ng/ml and is suitable for monitoring the drug in the therapeutic dose range and for investigation of the bioavailabilities of preparations of the drug.

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