A Potent Mutagen isolated from a Pyrolysate of L-Ornithine

MASAMI YOKOTA; KUSUO NARITA; TAKUO KOSUGE; KEIJI WAKABAYASHI; MINAKO NAGAO; TAKASHI SUGIMURA; KENTARO YAMAGUCHI; KOICHI SHUDO; YOICHI IITAKA; TOSHIHIKO OKAMOTO

doi:10.1248/cpb.29.1473

Chemical and Pharmaceutical Bulletin

Online ISSN : 1347-5223
Print ISSN : 0009-2363

A Potent Mutagen isolated from a Pyrolysate of L-Ornithine

MASAMI YOKOTA, KUSUO NARITA, TAKUO KOSUGE, KEIJI WAKABAYASHI, MINAKO NAGAO, TAKASHI SUGIMURA, KENTARO YAMAGUCHI, KOICHI SHUDO, YOICHI IITAKA, TOSHIHIKO OKAMOTO

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Keywords: X-ray structural analysis

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Volume 29 (1981) Issue 5 Pages 1473-1475

DOI https://doi.org/10.1248/cpb.29.1473

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Abstract

A potent mutagen was isolated from a pyrolysate of L-ornithine. The mutagenic activity of this compound on Salmonella typhimurium TA 98 was 28400 revertants/0.5 μg. This compound was deduced to be 4-amino-6-methyl-1H-2, 5, 10, 10b-tetraazafluoranthene by X-ray crystallographic analysis.

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