Further Studies on Dammarane-Saponins of American Ginseng, Roots of Panax quinquefolium L.

Abstract

Several Ginseng saponins, ginsenosides-Ro (1), -Rb₁ (2), -Rb₂ (3), -Rc (4), -Rd (5), and -Re (6), have already been isolated from American Ginseng, roots of Panax quinquefolium L. In the present work, further investigation of minor saponins of this plant drug led to the isolation and identification of ginsenosides-Rg₁ (7), -Rg₂ (8), -Rb₃ (9), and -F₂ (11), pseudogin-senoside-F₁₁ (10), and gypenoside-XVII (13). In addition to these known saponins, a new saponin named quinquenoside-R₁ (12) was also isolated and its structure was determined as mono-O-acetyl-ginsenoside-Rb₁ with the acetyl group located at the 6-hydroxyl group of the terminal glucosyl moiety of the β-sophorosyl group.