Synthesis of 3-(Dialkylamino) indolizines. Reaction of 3-(2-Pyridyl)-2-propenals with Secondary Amines

Abstract

Reaction of 2-or 3-substituted 3-(2-pyridyl)-2-propenals (3a-f) with secondary amines afforded 2-or 1-substituted 3-(dialkylamino) indolizines (2a-1) in the presence of metal halides. It was found that titanium tetrachloride was the best catalyst.