Studies on Fluorinated Pyrimidines. V. Preparation of optically Active (+)-and (-)-t-6-Butoxy-r-5-ethoxycarbonyl-5-fluoro-5, 6-dihydrouracils

Abstract

Both optical isomers of t-6-butoxy-r-5-ethoxycarbonyl-5-fluoro-5, 6-dihydrouracil (1, TAC-278), a new candidate for use as a pro-drug of 5-fluorouracil (5-FU), have been prepared via the enantiomeric 6-(+)-and 6-(-)-α-methylbenzylamino derivatives (4).