Preparation and Evaluation of Gelatin Microcapsules of Sulfonamides

Abstract

A simple microencapsulation of three sulfonamides (sulfanilamide, sulfisomidine and sulfamethizole) was investigated. The preparation is based on dispersion of a gelatinsulfonamide mixture in liquid paraffin, followed by drying and hardening with formalinisopropanol treatment. The microcapsules were recovered as a discrete, free-flowing powder with a particle diameter of 250-840μm. Dissolution of sulfamethizole from microcapsules approximated a zero-order release pattern from 0 to 10-30% dissolution. These microcapsules may be useful for studies related to sustained-release formulation.