Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Metabolites Produced by Aspergillus terreus var. aureus. I. Chemical Structures and Antimicrobial Activities of Metabolites Isolated from Culture Broth
YOSHIHIKO INAMORIYOSHIAKI KATOMAYURI KUBOTERUO KAMIKITSUNEMATSU TAKEMOTOKYOSUKE NOMOTO
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Keywords: questin
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1983 Volume 31 Issue 12 Pages 4543-4548

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Abstract

A fungus which was identified as Aspergillus terreus var. aureus showed antifungal and antibacterial activities. Through the investigation of its metabolites, six compounds (1-6) were isolated ; emodin (1), dihydrogeodin (2), questin (3), sulochrin (5), the new metabolite 2-(3-chloro-4-methyl-γ-resorcyloyl)-5-hydroxy-m-anisic acid methyl ester (4), which is a monochloro derivative of sulochrin (5), and compound (6), the chemical structure of which has not yet been clarified. Dihydrogeodin (2), sulochrin (5), 4 and 6 showed antifungal and antibacterial activities, and 6 had especially strong antifungal activity towards Trichophyton mentagrophytes.

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© The Pharmaceutical Society of Japan
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