Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
1, 6-Dihydro-3 (2H)-pyridinones. VIII. Total Synthesis of (±)-Corynantheidol and Formal Synthesis of (±)-Quinine
TAKESHI IMANISHIMAKOTO INOUEYASUAKI WADAMIYOJI HANAOKA
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Keywords: quinine
JOURNAL FREE ACCESS

1983 Volume 31 Issue 5 Pages 1551-1560

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Abstract
cis-3, 4-Disubstituted piperidine compounds (2 and 3) were stereoselectively prepared from benzyl 3-(1, 3-dioxolan-2-ylmethyl)-1, 2, 3, 6-tetrahydropyridine-1-carboxylate (13) via the ketone (17). A total synthesis of (±)-corynantheidol (4) and a formal synthesis of (±)-quinine (5) have also been achieved from the piperidines 2 and 3, respectively.
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© The Pharmaceutical Society of Japan
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