Synthesis and Activity of a newly Isolated Analgesic Pentapeptide, Neo-kyotorphin

KOUKI KITAGAWA; NOBUYUKI KAWAI; YOSHIAKI KISO; TADASHI AKITA; KIYOSHI FUKUI; HIROO AMANO; HIROSHI TAKAGI

doi:10.1248/cpb.31.2349

Chemical and Pharmaceutical Bulletin

Online ISSN : 1347-5223
Print ISSN : 0009-2363

Synthesis and Activity of a newly Isolated Analgesic Pentapeptide, Neo-kyotorphin

KOUKI KITAGAWA, NOBUYUKI KAWAI, YOSHIAKI KISO, TADASHI AKITA, KIYOSHI FUKUI, HIROO AMANO, HIROSHI TAKAGI

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Keywords: analgesic activity

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Volume 31 (1983) Issue 7 Pages 2349-2352

DOI https://doi.org/10.1248/cpb.31.2349

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Abstract

A newly isolated bovine brain pentapeptide, Thr-Ser-Lys-Tyr-Arg (neo-kyotorphin), which contains the Tyr-Arg (kyotorphin) unit at its carboxyl terminal portion, was synthesized by using the TFMSA-TFA-thioanisole deprotecting procedure. The synthetic peptide exhibited dosedependent analgesic activity in mice at a level approximately equal to that of Leu-enkephalin.

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