Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on the Mutagenicity of Swertiae Herba. II. Quantitative Analysis of Mutagenic Components by Thin Layer Chromatograph Densitometry
HISAYUKI KANAMORIIKUNORI SAKAMOTOMARI MIZUTAOSAMU TANAKA
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1984 Volume 32 Issue 12 Pages 4942-4945

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Abstract

Good separation of seven mutagenic xanthones present in Swertiae Herba was accomplished by thin-layer chromatography (TLC) on silica gel plates. The conditions for quantitative analysis of these xanthones by TLC-densitometry were investigated, and this TLC-densitometry was applied to the analysis of the constituents of the commercial Swertiae Herba and to the determination of the time courses of their extraction with hot water. The relationship between xanthone content and mutagenicity is discussed.

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© The Pharmaceutical Society of Japan
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