The effects of various flavonoids isolated from the roots of Scutellaria baicalensis on the histamine release from mast cells were investigated. Many of the flavonoids (wogonin, wogonin-7-O-D-glucuronide, baicalein, skullcapflavone II, (2S)-2', 5, 6', 7-tetrahydroxyflavanone, (2R, 3R)-2', 3, 5, 6', 7-pentahydroxyflavanone and 2', 5, 5', 7-tetrahydroxy-6', 8-dimethoxyflavone) inhibited the histamine release from rat mast cells induced by compound 48/80.
