Studies on the Chemical Constituents of Rutaceous Plants. LVI. The Development of a Versatile Method for the Synthesis of Antitumor-Active Benzo [c] phenanthridine Alkaloids. (6). Limitation of the Dyke Synthetic Pathway for Benzo [c] phenanthridine Alkaloids

Abstract

A limitation of the Dyke method for synthesizing benzo [c] phenanthridine alkaloids through the 1, 2-dihydroisoquinoline derivatives prepared by means of the Pomeranz-Fritsch reaction was clarified ; the method is not applicable to such alkaloids having an alkoxy group at the C₁₀ position.