Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Inhibitors of Angiotensin Converting Enzyme in Crude Drugs. I
JINICHI INOKUCHIHIKARU OKABETATSUO YAMAUCHIATSUO NAGAMATSU
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Keywords: tannin
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1984 Volume 32 Issue 9 Pages 3615-3619

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Abstract

Hot 50% MeOH extracts of crude drugs considered to have a hypotensive effect were tested for inhibitory effects on hog kidney angiotensin converting enzyme. Of 65 samples tested, 14 showed reproducible inhibition in the preliminary screening. The extracts of 8 potent samples were fractionated by MCI gel and Sephadex LH-20 gel chromatographies to concentrate the inhibitors. The most potent fractions of Arecae Semen, Ephedrae Herba, Epimedii Herba, Polygoni avicularis Herba, Potentillae Herba and Rhei Rhizoma showed more than 90% inhibition at the concentration of 20μg/ml. Those of Moutan Cortex and Cinnamomi Cortex showed 86 and 78% inhibitions, respectively, at the same concentration. All of these fractions consisted of tannin-type compounds.

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© The Pharmaceutical Society of Japan
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