Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Metabolism of Glycyrrhizin by Human Intestinal Flora. II. Isolation and Characterization of Human Intestinal Bacteria Capable of Metabolizing Glycyrrhizin and Related Compounds
MASAO HATTORITATSUYA SAKAMOTOTAKEYOSHI YAMAGISHIKENICHI SAKAMOTOKENICHI KONISHIKYOICHI KOBASHITSUNEO NAMBA
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1985 Volume 33 Issue 1 Pages 210-217

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Abstract

In a survey of intestinal bacteria capable of metabolizing glycyrrhizin (GL), Ruminococcus sp. PO1-3 and Clostridium innocuum ES24-06 were isolated from human feces. The former strain had the ability to hydrolyze GL to glycyrrhetic acid (GA) and to reduce 3-dehydroglycyrrhetic acid (DGA) to GA while the latter strain had the ability to reduce DGA to 3-epiglycyrrhetic acid (EGA). A mixture of the two strains could not only reduce DGA to both GA and EGA, but also epimerize GA to EGA and vice versa, possibly through a 3-dehydro intermediate.

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© The Pharmaceutical Society of Japan
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