Abstract
In order to examine the lipotropic and hypotensive effects of glutamylcholines, α-and γ-(Z-and Boc-glutamyl) cholines (4a, 4'a, 4b and 4'b) were synthesized by the removal of the tert-butyl and benzyl groups of the corresponding tert-butyl (3a and 3'a) and benzyl (3b and 3'b) choline esters which were obtained by the esterification of tert-butyl Z-glutamates (1a and 1'a) and benzyl Boc-glutamate dicyclohexylamine salts (1b and 1'b) with N, N-dimethylaminoethyl chloride, followed by methylation with methyl halide.
