ISOLATION AND CHARACTERIZATION OF A NEW 5-AMINOFURYLTHIAZOLE FROM THE CATALYTIC REDUCTION OF 4-(5-NITRO-2-FURYL) THIAZOLE

Abstract

As a new extension of catalytic hydrogenation of 4-(5-nitro-2-furyl) thiazole, a convenient procedure for the synthesis of 4-(5-amino-2-furyl) thiazole has been developed using tetrahydrofuran and n-heptane to isolate enough 5-amino compound to determine the empirical formula. The 5-aminofurylthiazole was converted to 4-(5-acetylamino-2-furyl) thiazole and 4-(5-benzoylamino-2-furyl) thiazole. The stability of the 5-aminofuran ring in the pH 4.0 to 9.0 region was measured kinetically.