Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
An Enantioselective Synthesis of Platelet-Activating Factors, Their Enantiomers, and Their Analogues from D-and L-Tartaric Acids
大野 雅二藤田 かがり中井 久雄小林 進井上 圭三野島 庄七
著者情報
ジャーナル フリー

1985 年 33 巻 2 号 p. 572-582

詳細
抄録

Acetyl glyceryl ether phosphorylcholines (platelet-activating factors ; PAFs), their enantiomers, and their analogues were efficiently synthesized in a stereochemically unambiguous manner starting from D-and L-tartaric acids as chiral synthons. The enantiomer of C16-PAF (S-comfiguration) showed far less activity than the natural PAF (R-configuration), and the N-methylpiperidine and N-methylpyrrolidine analogues were found to possess much higher activity than natural C16-PAF.

著者関連情報
© The Pharmaceutical Society of Japan
前の記事 次の記事
feedback
Top